Publication Date
2025
College
College of Natural Resources & Sciences
Department
Mathmatics
Document Type
Poster
Description
Alzheimer’s Disease (AD) is a neurological disorder that destroys memory and other cognitive functions. Several scientific findings have connected dysfunctional microglia, a type of immune cell, to AD progression. We created an agent-based model to simulate the interactions between microglia and their environment, addressing dysfunctional microglia's effect on AD. Our model represents a two-dimensional slice of the hippocampus, depicting microglia's ability to move, metabolize glucose, and interact with the blood brain barrier and amyloid beta plaques. We applied treatments of metabolic boosting and exercise to our model to study how varying treatment intensities can impede AD progression.