Since 1990, many Cal Poly Humboldt faculty and students have made cannabis the focus of scholarship and learning. This work has been shaped by the political, economic, and cultural legacies of cannabis in Humboldt County. Scholarly interest spans multiple dimensions of cannabis cultivation, commerce, consumption, and related social issues. As a multidisciplinary team of scholars, Cal Poly Humboldt faculty affiliated with the Humboldt Institute for Interdisciplinary Marijuana Research (HIIMR) have also shaped the Bachelor of Arts in Cannabis Studies that will launch in Fall 2023. This is the first social science degree program in the United States with this orientation. In this article we trace the origins of cannabis scholarship and learning at Cal Poly Humboldt from a period of domestic cannabis prohibition to the recent period of industry legalization. We also provide an overview of the BA program links to local and state policy and other contexts. Finally, we discuss cultivation communities and strategies of resilience in the context of economic turmoil as a result of legalization.